Objective: To investigate the current status, hotspots and frontiers trends of low glycemic index(LGI) through bibliometric analysis. Methods: We searched all research publications related to LGI from 2003 to 2022 on the Web of Scientific Core Collection(WoSCC). CiteSpace and VOSviewer software was used to analyze the cooperative relationships between countries, institutions, and authors, conduct co-occurrence analysis, cluster analysis, keyword burst analysis, and to analysis the co citation situation of cited journals and literature, and drawing a visual graph.selleckchem Results: A total of 5867 papers were included, with an increasing trend of annual publication. LCD categories mainly included Nutrition Dietetics, Food Science Technology and Endocrinology Metabolism which reflected the interdisciplinary characteristics. The United States was the largest research center of the whole world in the field of LGI. Universities were main research institutions purine biosynthesisand five of the top 10 institutions were from USA. American Journal of Clinical Nutrition was the leading journal. The hotspots of LCD are five aspects, “diabetes”, “glycemic index”, “glycemic load”, “diet”, “insulin”. We summarized that “irBelnacasan配制ritable bowel syndrome”, “antioxidant property”, and “celiac disease” are becoming frontiers trends of LCD research in the future and deserve further study. Conclusions: Over the past 20 years, research on LCD has received great attention. In order to explore LCD field better, multi-level mechanism research will be required in the future.